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Scientists Propose New Theory on Alzheimer's, Amyloid Connection

Apr 23, 2019 07:47 AM EDT

(Photo : pixabay)
New Theory on Alzheimer's, Amyloid Connection (IMAGE)
The background is an image of neurons (blue). Some of them express the new amyloid precursor protein reporter (green) and a synapse-marker, Synaptophysin-pHTomato (red). The rendering at the lower left corner illustrates the Alzheimer's disease etiology model derived from the study, in which a variety of pathological contributors like aging and Abeta converge on presynaptic cholesterol and the disruption of cholesterol homeostasis diverges to various pathological outcomes like synaptic dysfunction and neuronal loss.
(Photo : Qi Zhang, Ph.D. and Claire E. DelBove)

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